Drugs and the elderly patient.
Identifieur interne : 000402 ( Main/Exploration ); précédent : 000401; suivant : 000403Drugs and the elderly patient.
Auteurs : Samer A. Bsoul [États-Unis] ; Geza TerezhalmySource :
- General dentistry [ 0363-6771 ]
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Effets secondaires indésirables des médicaments (MeSH), Homéostasie (physiologie), Humains (MeSH), Observance par le patient (MeSH), Pharmacocinétique (MeSH), Pharmacologie (MeSH), Préparations pharmaceutiques (métabolisme), Rein (métabolisme), Récepteurs de surface cellulaire (analyse), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Traitement médicamenteux (MeSH), Transduction du signal (physiologie), Vieillissement (métabolisme), Vieillissement (physiologie).
- MESH :
- analyse : Récepteurs de surface cellulaire.
- métabolisme : Préparations pharmaceutiques, Rein, Vieillissement.
- physiologie : Homéostasie, Transduction du signal, Vieillissement.
- Adulte, Adulte d'âge moyen, Effets secondaires indésirables des médicaments, Humains, Observance par le patient, Pharmacocinétique, Pharmacologie, Sujet âgé, Sujet âgé de 80 ans ou plus, Traitement médicamenteux.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Aging (metabolism), Aging (physiology), Drug Therapy (MeSH), Drug-Related Side Effects and Adverse Reactions (MeSH), Homeostasis (physiology), Humans (MeSH), Kidney (metabolism), Middle Aged (MeSH), Patient Compliance (MeSH), Pharmaceutical Preparations (metabolism), Pharmacokinetics (MeSH), Pharmacology (MeSH), Receptors, Cell Surface (analysis), Signal Transduction (physiology).
- MESH :
- chemical , analysis : Receptors, Cell Surface.
- chemical , metabolism : Pharmaceutical Preparations.
- metabolism : Aging, Kidney.
- physiology : Aging, Homeostasis, Signal Transduction.
- Adult, Aged, Aged, 80 and over, Drug Therapy, Drug-Related Side Effects and Adverse Reactions, Humans, Middle Aged, Patient Compliance, Pharmacokinetics, Pharmacology.
Abstract
The rational use of drugs in older persons is a challenging area of clinical practice. The increased incidence of multiple chronic illnesses contributes to disproportionately high use of prescription and over-the-counter (OTC) medications, which in turn leads to more adverse drug events among the elderly. Inadequate nutrition and poor patient compliance also may contribute to the problem. Drug studies that use young adult subjects cannot be extrapolated accurately to apply to the elderly because physiologic changes that occur with age affect the pharmacokinetics and pharmacodynamics of drugs. In addition, therapeutic target concentrations of drugs are impossible to define due to marked interindividual variation in the elderly population. Drugs should be administered to elderly patients only when absolutely necessary. The dosages should be titrated to a clearly defined clinical response and dentists should avoid drugs that are known to be problematic for older adults.
PubMed: 17511370
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Bsoul</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dental Diagnostic Science, University of Texas Health Science Center, San Antonio Dental School, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dental Diagnostic Science, University of Texas Health Science Center, San Antonio Dental School</wicri:regionArea><wicri:noRegion>San Antonio Dental School</wicri:noRegion></affiliation></author><author><name sortKey="Terezhalmy, Geza" sort="Terezhalmy, Geza" uniqKey="Terezhalmy G" first="Geza" last="Terezhalmy">Geza Terezhalmy</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007 May-Jun</date><idno type="RBID">pubmed:17511370</idno><idno type="pmid">17511370</idno><idno type="wicri:Area/Main/Corpus">000417</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000417</idno><idno type="wicri:Area/Main/Curation">000417</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000417</idno><idno type="wicri:Area/Main/Exploration">000417</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Drugs and the elderly patient.</title><author><name sortKey="Bsoul, Samer A" sort="Bsoul, Samer A" uniqKey="Bsoul S" first="Samer A" last="Bsoul">Samer A. Bsoul</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dental Diagnostic Science, University of Texas Health Science Center, San Antonio Dental School, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dental Diagnostic Science, University of Texas Health Science Center, San Antonio Dental School</wicri:regionArea><wicri:noRegion>San Antonio Dental School</wicri:noRegion></affiliation></author><author><name sortKey="Terezhalmy, Geza" sort="Terezhalmy, Geza" uniqKey="Terezhalmy G" first="Geza" last="Terezhalmy">Geza Terezhalmy</name></author></analytic><series><title level="j">General dentistry</title><idno type="ISSN">0363-6771</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Aging (metabolism)</term><term>Aging (physiology)</term><term>Drug Therapy (MeSH)</term><term>Drug-Related Side Effects and Adverse Reactions (MeSH)</term><term>Homeostasis (physiology)</term><term>Humans (MeSH)</term><term>Kidney (metabolism)</term><term>Middle Aged (MeSH)</term><term>Patient Compliance (MeSH)</term><term>Pharmaceutical Preparations (metabolism)</term><term>Pharmacokinetics (MeSH)</term><term>Pharmacology (MeSH)</term><term>Receptors, Cell Surface (analysis)</term><term>Signal Transduction (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Effets secondaires indésirables des médicaments (MeSH)</term><term>Homéostasie (physiologie)</term><term>Humains (MeSH)</term><term>Observance par le patient (MeSH)</term><term>Pharmacocinétique (MeSH)</term><term>Pharmacologie (MeSH)</term><term>Préparations pharmaceutiques (métabolisme)</term><term>Rein (métabolisme)</term><term>Récepteurs de surface cellulaire (analyse)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Traitement médicamenteux (MeSH)</term><term>Transduction du signal (physiologie)</term><term>Vieillissement (métabolisme)</term><term>Vieillissement (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Receptors, Cell Surface</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Pharmaceutical Preparations</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Récepteurs de surface cellulaire</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Aging</term><term>Kidney</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Préparations pharmaceutiques</term><term>Rein</term><term>Vieillissement</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Homéostasie</term><term>Transduction du signal</term><term>Vieillissement</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aging</term><term>Homeostasis</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Drug Therapy</term><term>Drug-Related Side Effects and Adverse Reactions</term><term>Humans</term><term>Middle Aged</term><term>Patient Compliance</term><term>Pharmacokinetics</term><term>Pharmacology</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Effets secondaires indésirables des médicaments</term><term>Humains</term><term>Observance par le patient</term><term>Pharmacocinétique</term><term>Pharmacologie</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Traitement médicamenteux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The rational use of drugs in older persons is a challenging area of clinical practice. The increased incidence of multiple chronic illnesses contributes to disproportionately high use of prescription and over-the-counter (OTC) medications, which in turn leads to more adverse drug events among the elderly. Inadequate nutrition and poor patient compliance also may contribute to the problem. Drug studies that use young adult subjects cannot be extrapolated accurately to apply to the elderly because physiologic changes that occur with age affect the pharmacokinetics and pharmacodynamics of drugs. In addition, therapeutic target concentrations of drugs are impossible to define due to marked interindividual variation in the elderly population. Drugs should be administered to elderly patients only when absolutely necessary. The dosages should be titrated to a clearly defined clinical response and dentists should avoid drugs that are known to be problematic for older adults.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17511370</PMID><DateCompleted><Year>2007</Year><Month>06</Month><Day>19</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0363-6771</ISSN><JournalIssue CitedMedium="Print"><Volume>55</Volume><Issue>3</Issue><PubDate><MedlineDate>2007 May-Jun</MedlineDate></PubDate></JournalIssue><Title>General dentistry</Title><ISOAbbreviation>Gen Dent</ISOAbbreviation></Journal><ArticleTitle>Drugs and the elderly patient.</ArticleTitle><Pagination><MedlinePgn>238-43; quiz 244, 264</MedlinePgn></Pagination><Abstract><AbstractText>The rational use of drugs in older persons is a challenging area of clinical practice. The increased incidence of multiple chronic illnesses contributes to disproportionately high use of prescription and over-the-counter (OTC) medications, which in turn leads to more adverse drug events among the elderly. Inadequate nutrition and poor patient compliance also may contribute to the problem. Drug studies that use young adult subjects cannot be extrapolated accurately to apply to the elderly because physiologic changes that occur with age affect the pharmacokinetics and pharmacodynamics of drugs. In addition, therapeutic target concentrations of drugs are impossible to define due to marked interindividual variation in the elderly population. Drugs should be administered to elderly patients only when absolutely necessary. The dosages should be titrated to a clearly defined clinical response and dentists should avoid drugs that are known to be problematic for older adults.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bsoul</LastName><ForeName>Samer A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Department of Dental Diagnostic Science, University of Texas Health Science Center, San Antonio Dental School, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Terezhalmy</LastName><ForeName>Geza</ForeName><Initials>G</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Gen Dent</MedlineTA><NlmUniqueID>7610466</NlmUniqueID><ISSNLinking>0363-6771</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004364">Pharmaceutical Preparations</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011956">Receptors, Cell Surface</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000375" MajorTopicYN="N">Aging</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004358" MajorTopicYN="Y">Drug Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064420" MajorTopicYN="N">Drug-Related Side Effects and Adverse Reactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006706" MajorTopicYN="N">Homeostasis</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007668" MajorTopicYN="N">Kidney</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010349" MajorTopicYN="N">Patient Compliance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004364" MajorTopicYN="N">Pharmaceutical Preparations</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010599" MajorTopicYN="N">Pharmacokinetics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010600" MajorTopicYN="N">Pharmacology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011956" MajorTopicYN="N">Receptors, Cell Surface</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>5</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>6</Month><Day>20</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>5</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17511370</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Terezhalmy, Geza" sort="Terezhalmy, Geza" uniqKey="Terezhalmy G" first="Geza" last="Terezhalmy">Geza Terezhalmy</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Bsoul, Samer A" sort="Bsoul, Samer A" uniqKey="Bsoul S" first="Samer A" last="Bsoul">Samer A. 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